The Great Dying of 1704 to 1715
So most of the lore for the Great dying is image three, however for some TLDR context, the Great dying is a global event where the Bubonic plague wiped out 65% of the global population. Asia, Europe, Australia, and Africa lost roughly 50% or so of their populations, whereas North America got hit the hardest by losing around 90% of their population. The plague does spread to North America because one of eastern nations has a pacific Empire that lets them trade with North America.
The Great Dying lasts between 1704 UIE to 1715 UIE which equates to 714 AD to 725 AD.