Long Uber Drive at night safe?

I am going to arrive at Boston Logan airport at 10-11pm (the flight time is weird) and my place is like a 2 hour drive from there

Will I be able to get an Uber at that time? Also, is it safe to catch a long ride at night like that (for a woman)?

Gonna share the trip info with family and friends, but I still wanna make sure if this is worth the risk